期刊
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
卷 30, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nano.2020.102291
关键词
PLGA; Nanoparticles; Lungs; Clearance; Pharmacokinetics
资金
- Victoria India doctoral scholarship
- NHMRC Career Development fellowship
- ARC
- NHMRC
Polylactide-co-glycolide (PLGA) nanoparticles are one of the most commonly explored biodegradable polymeric drug carriers for inhaled delivery. Despite their advantages as inhalable nanomedicine scaffolds, we still lack a complete understanding of the kinetics and major pathways by which these materials are cleared from the lungs. This information is important to evaluate their safety over prolonged use and enable successful clinical translation. This study aimed to determine how the size and charge of H-3-labeled PLGA nanoparticles affect the kinetics and mechanisms by which they are cleared from the lungs and their safety in the lungs. The results showed that lung clearance kinetics and retention patterns were more significantly defined by particle size, whereas lung clearance pathways were largely influenced by particle charge. Each of the nanoparticles caused transient inflammatory changes in the lungs after a single dose that reflected lung retention times. (C) 2020 Elsevier Inc. All rights reserved.
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