Synthesis and Characterization of Pectin Membrane as a Matrix for Curcumin Sustained-Release

This study aims to synthesize pectin membranes, characterization of pectin membranes use FTIR, XRD, SEM, and to see the loading of curcumin in pectin membranes as a drug delivery system by contact time variations. Pectin membrane synthesize by dissolved 0.5 gram of pectin powder in 25 ml of 2% acetic acid solution then stirred for 1 hour. The solution is molded in membrane mold then oven for 24 hours at 50 degrees C. Pectin membranes were characterized by FTIR to determine functional groups, XRD test to determine crystallinity, and SEM test to determine the surface morphology. The loading of curcumin in pectin membrane are carried out by contacting the pectin membrane into 100 ppm curcumin at various times of 5 to 120 minutes. Determination of curcumin concentration contained in pectin membrane use UV-Vis spectrophotometer at lambda 426 nm. The results showed that the produced of pectin membrane was thin, pellucid, and homogeneous sheets. The results of FTIR characterization showed OH group at wave number 3448.72 cm(-1) and carbonyl group at wave number 1604.77 cm(-1). XRD characterization result showed that the pectin membrane was amorf. SEM characterization results showed smooth and flat surface morphology. The optimum contact time in loading curcumin proses in pectin membrane was 60 minutes with a loading percentage of 10%.