期刊
FOOD RESEARCH INTERNATIONAL
卷 137, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.foodres.2020.109450
关键词
Probiotic; Whey dairy beverages; Prostate cancer; Antiproliferative activity; Apoptotic effect
资金
- Fundacao de Amparo e Apoio a Pesquisa no Rio de Janeiro (FAPERJ) [228434, 227094]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brazil -(CAPES) [001]
- Conselho Nacional de Pesquisa Cientifica (CNPQ)
- FAPERJ
- CNPQ
- CAPES
The present study aimed to evaluate the antiproliferative and apoptotic effects of probiotic whey dairy beverages in human prostate cancer cell lines (PC-3 and DU-145). Five different whey beverages were manufactured: conventional whey beverage (without addition of probiotic strain, CTL); and whey beverages containing Lactobacillus acidophilus La-05, Lactobacillus acidophilus La-03, Lactobacillus casei-01, and Bifidobacterium animalis Bb-12. Cell viability was determined by MTT assay and cell cycle arrest, and apoptosis by flow cytometry. All the samples presented cytotoxic activities against both cell lines. A decrease in the percentage of PC-3 cells in G(0)/G(1) and S, followed by an increase in G(2)/M phase were observed with L. casei-01, Bb-12 and La-05 beverages (50.0 and 100.0 mu g/mL). The extracts of the whey beverages caused extensive apoptosis induction in both cells' lines, regardless of the probiotic strain. However, the whey beverage added with L. casei-01 might be a better candidate against prostate cancer cells.
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