期刊
BIOSCIENCE REPORTS
卷 40, 期 -, 页码 -出版社
PORTLAND PRESS LTD
DOI: 10.1042/BSR20201946
关键词
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资金
- National Natural Science Foundation of China [81600685, 81901517]
- Nanjing Medical Science and Technique Development Foundation [QRX17163]
- 333 high level talents training project of Jiangsu Province
- Six talent peaks project in Jiangsu Province [WSN-121]
- Wuxi Key Medical Disciplines [ZDXK012]
- Medical Innovation Team of Jiangsu Province [CXTDB2017016]
- Wuxi Medical Development Discipline [FZXK001]
- Wuxi Young and Middle-aged Medical Talents [QNRC094, BJ020089]
- Young project of Wuxi health and Family Planning Commission [Q201815]
- Jiangsu maternal and child health research project [F2018525]
- Wuxi maternal and child health research project [FYKY201807]
- Project of Wuxi health Commission [M202003]
- Wuxi Science and Technology Development Fund [N20192039]
Circular RNA (circRNA) is a novel member of endogenous noncoding RNAs with widespread distribution and diverse cellular functions. Recently, circRNAs have been identified for their enrichment and stability in exosomes. However, the roles of circRNAs from umbilical cord blood exosomes in gestational diabetes mellitus (GDM) occurrence and fetus growth remains poorly understood. In the present study, we used microarray technology to construct a comparative circRNA profiling of umbilical cord blood exosomes between GDM patients and controls. We found the exosome particle size was larger, and the exosome concentration was higher in the GDM patients. A total of 88,371 circRNAs in umbilical cord blood exosomes from two groups were evaluated. Of these, 229 circRNAs were significantly up-regulated and 278 circRNAs were significantly down-regulated in the GDM patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) biological pathway analyses demonstrated that circRNA parental genes involved in the regulation of metabolic process, growth and development were significantly enriched, which are important in GDM development and fetus growth. Further circRNA/miRNA interactions analysis showed that most of the exosomal circRNAs harbored miRNA binding sites, and some miRNAs were associated with GDM. Collectively, these results lay a foundation for extensive studies on the role of exosomal circRNAs in GDM development and fetus growth.
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