期刊
ANALYTICAL CHEMISTRY
卷 92, 期 22, 页码 15229-15235出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c03936
关键词
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资金
- National Natural Science Foundation of China [21735004, 21874089, 21775128, 21974112, 21705024]
- Fujian Medical Innovation Project [2018-CXB25]
- Xiamen Science and Technology Key Program [3502Z20179043]
- Program for Chang Jiang Scholars, and Innovative Research Teams in University [IRT13036]
As a malignant disease that seriously threatens human health, hepatocellular carcinoma (HCC) lacks effective early screening and prognostic assessment methods. Herein, we developed a method for efficient capture and multiphenotype analysis of circulating tumor cells (CTCs) of hepatocellular carcinoma. The anti-ASGPR antibody and the anti-EpCAM antibody were modified in parallel on a deterministic lateral displacement (DLD)-patterned microfluidic Synergetic-Chip to enhance capture efficiency by a complementary effect. CTCs were detected in 45 out of 45 (100%) HCC patients, with a sensitivity and specificity of 97.8 and 100%, respectively. Patients with more total CTCs and nonepithelial CTCs were in later stages of HCC and had more malignant progression. This strategy proposes a feasible approach for early diagnosis and prognosis of hepatocellular carcinoma.
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