期刊
FOOD & FUNCTION
卷 11, 期 12, 页码 10876-10885出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo02575e
关键词
-
资金
- Natural Science Foundation of Guangdong Province [2017A030313045, 2019A1515011670]
- National Natural Science Foundation of China [31972011]
- Guangzhou Science and Technology Program [201907010035]
- 111 project [B17018]
- Fundamental Research Funds for the Central Universities [2019MS101]
A sulfated polysaccharide extracted from Gracilaria lemaneiformis (GLP) with a prominent effect in regulating lipid metabolism was isolated. The molecular weight was 31.5 kDa and it was composed mainly of galactose, glucose and xylose. Fourier-transform infrared (FT-IR) spectrum and nuclear magnetic resonance (NMR) analysis suggested that GLP was composed of the following repeating unit: [3-beta-Gal-4(OSO3)-1 -> 4-alpha-3,6-anhydrogal-2(OSO3)-1 ->]. GLP could significantly decrease serum total cholesterol, triglyceride and free fatty acid levels and lower alanine aminotransferase and aspartate aminotransferase activities in high-fat-diet mice. Additionally, GLP could keep the body weight and attenuate accumulation of fat surrounding the liver and epididymis induced by high-fat diet. Results of RT-PCR indicated that GLP might regulate lipid metabolism and accelerate free fatty acid oxidation by up-regulating the expression of the PPAR alpha, ACS and CPT1a gene. The present study suggests that GLP may be potentially useful for regulating lipid metabolism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据