期刊
ORGANIC LETTERS
卷 22, 期 22, 页码 8978-8983出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c03382
关键词
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资金
- Northwestern Polytechnical University
- Fundamental Research Funds for the Central Universities
- Natural Science Foundation of Jiangsu Province [BK20171463]
- grant of MOE-Tier 1 [M4012045.110 RG12/18-(S)]
- students' project of Nanjing Tech University for innovation and entrepreneurship training program [2020DC0397]
- Nanjing Tech University
- Nanyang Technological University
This paper reports a highly site-selective alkylation of heteroarene N-oxides using hypervalent iodine(III) carboxylates to serve as an alkylating agent in the presence of a cheap copper catalyst under visible light conditions. This mild method proceeds at room temperature in an air atmosphere and can withstand various heteroarene N-oxides as well as various primary, secondary, and tertiary alkyl carboxylic acids. It also provides a practical method for enabling the rapid conversion of commercially available raw materials into medically relevant drug-like molecules.
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