期刊
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
卷 19, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1533033820980116
关键词
abnormal blood vessels; tumor microenvironment; anti-angiogenesis; tumor vessels normalization; immune checkpoint blockers
类别
资金
- Natural Science Foundation of Zhejiang Province [LQ18H280006]
- Medical Science & Technology Program of Zhejiang Province, China [2019RC021]
Hostile microenvironment produced by abnormal blood vessels, which is characterized by hypoxia, low pH value and increasing interstitial fluid pressure, would facilitate tumor progression, metastasis, immunosuppression and anticancer treatments resistance. These abnormalities are the result of the imbalance of pro-angiogenic and anti-angiogenic factors (such as VEGF and angiopoietin 2, ANG2). Prudent use of anti-angiogenesis drugs would normalize these aberrant tumor vessels, resulting in a transient window of vessel normalization. In addition, use of cancer immunotherapy including immune checkpoint blockers when vessel normalization is achieved brings better outcomes. In this review, we sum up the advances in the field of understanding and application of the concept of tumor vessels normalization window to treat cancer. Moreover, we also outline some challenges and opportunities ahead to optimize the combination of anti-angiogenic agents and immunotherapy, leading to improve patients' outcomes.
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