期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 48, 期 6, 页码 2557-2564出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20200239
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资金
- INFN Sezione di Padova [HAS-11015, GINOP-2.3.2-15-2016-00044]
Why proteins are fuzzy? Constant adaptation to the cellular environment requires a wide range of changes in protein structure and interactions. Conformational ensembles of disordered proteins in particular exhibit large shifts to activate or inhibit alternative pathways. Fuzziness is critical for liquid-liquid phase separation and conversion of biomolecular condensates into fibrils. Interpretation of these phenomena presents a challenge for the classical structure-function paradigm. Here I discuss a multi-valued formalism, based on fuzzy logic, which can be applied to describe complex cellular behavior of proteins.
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