期刊
BIOMEDICAL OPTICS EXPRESS
卷 11, 期 12, 页码 7109-7119出版社
Optica Publishing Group
DOI: 10.1364/BOE.406097
关键词
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资金
- National Natural Science Foundation of China [61975031, 11974077, 61575043, 81741008]
- Innovation Team Development Plan, Ministry of Education [IRT_15R10]
- Special Funds of the Central Government Guiding Local Science and Technology Development [17L3009, 2020L3008]
- United Fujian Provincial Health and Education Project for Tackling the Key Research, China [2019-WJ-03]
- Startup Fund for scientific research, Fujian Medical University [2017XQ1209]
- Natural Science Foundation of Fujian Province [2020J011121]
- program for Industry-University Cooperation Project of Fujian Province [2020Y4006]
The concept of being able to urinate in a cup and screen for colorectal cancer (CRC) is fascinating to the public at large. Here, a simple and label-free urine test based on surface-enhanced Raman spectroscopy (SERS) was employed for CRC detection. Significant spectral differences among normal, stages I-II, and stages III-IV CRC urines were observed. Using discriminant function analysis, the diagnostic sensitivities of 95.8%, 80.9%, and 84.3% for classification of normal, stages I-II, and stages III-IV CRC were achieved in training model, indicating the great promise of urine SERS as a rapid, convenient and noninvasive method for CRC staging detection. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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