期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 48, 页码 9873-9882出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob01987a
关键词
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资金
- National Natural Science Foundation of China [NSFC 81602952]
- Natural Science Foundation of Jiangsu Province [BK20160748]
- Project Program of Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University [2018KFKT-3]
Herein we describe the PhI(OAc)(2)-mediated 1,1- and 1,2-difunctionalization of alkenes with N-tosyl amino alcohols to form oxazolidine and morpholine derivatives. This transformation was realized under mild reaction conditions and allows application to various substrates furnishing the multi-substituted oxazolidines and morpholines with yields up to 98%. A deuterium-labeling experiment was carried out and the result indicated that a phenyl group migration occurred to generate oxazolidine products.
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