期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 18, 期 48, 页码 9826-9830出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0ob02159h
关键词
-
资金
- National Research Foundation [NRF-2020R1F1A1068452, NRF-2020R1A4A2002831]
- Korea Basic Science Institute (KBSI) National Research Facilities & Equipment Center (NFEC) - Korea government (Ministry of Education) [2019R1A6C1010042]
A Pd-catalyzed asymmetric [5 + 2] cycloaddition reaction was developed for the synthesis of N-fused 1,3-oxazepines using vinylethylene carbonates and sulfamate-derived cyclic imines. Under mild reaction conditions, a series of optically active N-fused 1,3-oxazepines were synthesized in good yields (up to 89%) and enantioselectivities (up to 90 : 10 er), indicating this method as a straightforward approach to enantiomerically enriched 1,3-oxazepine derivatives. The synthetic utility of the presented reaction was further demonstrated by the successful transformation of the resulting 1,3-oxazepines to useful polycyclic N-fused 1,3-oxazepanes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据