期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 5, 期 7, 页码 699-714出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.04.015
关键词
acute myocardial infarction; adjunctive therapy; large animal model; mitochondrial-derived peptide; myocardial ischemia-reperfusion injury
资金
- National Institutes of Health, National Heart, Lung, and Blood Institute [1R56HL137711, 1R44 HL139161, 1R44 HL139195, 1R01 HL116571]
- American Heart Association [18POST34020143]
With the complexities that surround myocardial ischemia/reperfusion (MI/R) injury, therapies adjunctive to reperfusion that elicit beneficial pleiotropic effects and do not overlap with standard of care are necessary. This study found that the mitochondrial-derived peptide S14G-humanin (HNG) (2 mg/kg), an analogue of humanin, reduced infarct size in a large animal model of MI/R. However, when ischemic time was increased, the infarct-sparing effects were abolished with the same dose of HNG. Thus, although the 60-min MI/R study showed that HNG cardioprotection translates beyond small animal models, further studies are needed to optimize HNG therapy for longer, more patient-relevant periods of cardiac ischemia. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据