期刊
IEEE SENSORS JOURNAL
卷 17, 期 13, 页码 3961-3966出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JSEN.2017.2703834
关键词
Organic bioelectronics; displacement current extracellular electrodes; organ-on-a-chip
资金
- Portuguese Foundation for Science and Technology through the Implantable Organic Devices for Advanced Therapies Project [PTDC/EEI-AUT/5442/2014]
- Instituto de Telecomunicacoes [UID/Multi/04326/2013]
- Fundação para a Ciência e a Tecnologia [PTDC/EEI-AUT/5442/2014] Funding Source: FCT
Conducting polymer electrodes based on poly (3, 4 ethylenedioxythiophene): polystyrene sulfonate were used to record electrophysiological signals from autonomous cardiac contractile cells present in embryoid bodies. Signal detection was carried out by measuring the displacement current across the polymer/electrolyte double-layer capacitance, and compared with voltage detection. While for relatively low capacitance electrodes, the voltage amplification provides higher signal quality, and for high capacitive electrodes, the displacement current method exhibits a higher signal-to-noise ratio. It is proposed that the displacement current method combined with high capacitive polymer-based electrodes is adequate to measure clusters of cells and whole organs. Our approach has a great potential in fundamental studies of drug discovery and safety pharmacology.
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