期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 5, 期 9, 页码 931-945出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.07.009
关键词
cardiac fibrosis; heart failure; Hippo signaling; myocardial infarction; YAP
资金
- National Institutes of Health [HL127339, HL135726]
Fibrotic remodeling of the heart in response to injury contributes to heart failure, yet therapies to treat fibrosis remain elusive. Yes-associated protein (YAP) is activated in cardiac fibroblasts by myocardial infarction, and genetic inhibition of fibroblast YAP attenuates myocardial infarction-induced cardiac dysfunction and fibrosis. YAP promotes myofibroblast differentiation and associated extracellular matrix gene expression through engagement of TEA domain transcription factor 1 and subsequent de novo expression of myocardin-related transcription factor A. Thus, fibroblast YAP is a promising therapeutic target to prevent fibrotic remodeling and heart failure. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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