期刊
ISCIENCE
卷 23, 期 11, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2020.101756
关键词
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资金
- Universite de Paris
- Ecole Doctorale FIRE -Program Bettencourt
- Institut Pierre-Gilles de Gennes (laboratoire d'excellence, Investissements d'avenir program) [ANR-10-IDEX-0001-02 PSL, ANR-10-LABX-31]
- Human Frontier Science Program [RGY0077/2019]
- Canada Social Sciences and Humanities Research Council [430-2018-00899]
- Canada Research Chairs [CRC-950-230795]
- ESPCI Joliot Chair
Thresholds are widespread in origin of life scenarios, from the emergence of chirality, to the appearance of vesicles, of autocatalysis, all the way up to Darwinian evolution. Here, we analyze the error threshold,which poses a condition for sustaining polymer replication, and generalize the threshold approach to other properties of prebiotic systems. Thresholds provide theoretical predictions, prescribe experimental tests, and integrate interdisciplinary knowledge. The coupling between systems and their environment determines how thresholds can be crossed, leading to different categories of prebiotic transitions. Articulating multiple thresholds reveals evolutionary properties in prebiotic scenarios. Overall, thresholds indicate how to assess, revise, and compare origin of life scenarios.
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