期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 5, 期 4, 页码 387-397出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.03.010
关键词
animal research; drug development; toxicity; translational research
Dramatically rising costs in drug development are in large part because of the high failure rates in clinical phase trials. The poor correlation of animal studies to human toxicity and efficacy have led many developers to question the value of requiring animal studies in determining which drugs should enter in-human trials. Part 1 of this 2-part series examined some of the data regarding the tack of concordance between animal toxicity studies and human trials, as well as some of the potential reasons behind it. This second part of the series focuses on some alternatives to animal trials (hereafter referred to as animal research) as well as current regulatory discussions and developments regarding such alternatives. (C) 2020 The Author. Published by Elsevier on behalf of the American College of Cardiology Foundation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据