期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 48, 页码 11063-11073出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb02069a
关键词
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资金
- National Natural Science Foundation of China [82070695, 81900619]
- Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease [2019B030301004]
- Postdoctoral Science Foundation of China [2018M630936, 2018M643252]
- SIAT Innovation Program for Excellent Young Researchers [Y8G032]
- Chinese Academy of Sciences President's International Fellowship Initiative [2019PM0006]
Reconstruction of peripheral nerve defects with tissue engineered nerve scaffolds is an exciting field of biomedical research and holds potential for clinical application. However, due to poor neovascularization after the implantation, nerve regeneration is still not satisfactory, especially for large nerve defects. These obstacles hinder the investigation of basic neurobiological principles and development of a wide range of treatments for peripheral nerve diseases. Herein, we designed an amphiphilic alternating block polyurethane (abbreviated as PU) copolymer-based nerve guidance scaffold, which has good Schwann cell compatibility, and more importantly, a rapid vascularization of the scaffold in vivo. In the sciatic nerve transection model of SD rats, vascularized PU nerve guidance scaffolds induced rapid regeneration of nerve fibers and axons along the scaffold. Through the analysis of nerve electrophysiology, sciatic nerve functional index, histology, and immunofluorescence related to angiogenesis, we determined that PU with rapid vascularization function enhances recovery and re-obtains nerve conduction function. Our study points out a new strategy of using nerve tissue engineering scaffolds to treat large nerve defects.
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