期刊
BREAST CANCER-BASIC AND CLINICAL RESEARCH
卷 14, 期 -, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/1178223420977845
关键词
Breast cancer cell model; breast cancer young women; Cell lines; microRNAs
类别
资金
- Ministry of Economy and Competitiveness
- Carlos III Health Institute [PI13/00606]
- FEDER
- FPU pre-doctoral fellowship from MECD (Spanish Government) [FPU13/04976]
- Miguel Servet II contract from the Carlos III Health Institute [CPII14-00013]
- Foundation LeCado
Purpose: The study of breast cancer nearly always involves patients close to menopause or older. Therefore, young patients are mostly underrepresented. Our aim in this study was to demonstrate biological differences in breast cancer of young people using as a model available cell lines derived from people with breast cancer younger than 35 years. Methods: Global miRNA expression was analyzed in breast cancer cells from young (HCC1500, HCC1937) and old patients (MCF-7, MDA-MB-231, HCC1806, and MDA-MB-468). In addition, it was compared with same type of results from patients. Results: We observed a differential profile for 155 miRNAs between young and older cell lines. We identified a set of 24 miRNA associated with aggressiveness that were regulating pluripotency of stem cell-related pathways. Combining the miRNA expression data from cell lines and breast cancer patients, 132 miRNAs were differently expressed between young and old samples, most of them previously found in cell lines. MiR-23a-downregulation was also associated with poor survival in young patients. Conclusions: Our results suggest that HCC1500 and HCC1937 cell lines could be suitable cellular models for breast cancer affecting young women. The miR23a-downregulation could have a potential role as a poor prognosis biomarker in this age group.
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