期刊
ANNALS OF REHABILITATION MEDICINE-ARM
卷 44, 期 6, 页码 468-480出版社
KOREAN ACAD REHABILITATION MEDICINE
DOI: 10.5535/arm.20100
关键词
Heart septal defects; Atrial; Pulmonary arterial hypertension; Exercise therapy; Quality of life; Physical functional performance
资金
- Research Grant Pene-litian Dasar 2019 from Direktorat Riset dan Pengabdian Masyarakat, Direktorat Jenderal Penguatan Riset dan Pengem-bangan, Kementerian Riset, Teknologi dan Pendidikan Tinggi of Indonesia via Universitas Gadjah Mada, Jogjakarta, Indonesia [2798/UN1. DITLIT/DIT-LIT/LT/2019]
Objective To assess the effect of combined hospital and home-based exercise programs on functional capacity and quality of life (QoL) among uncorrected atrial septal defect-associated pulmonary arterial hypertension (ASD-PAH) patients. Methods This study was a randomized controlled trial with uncorrected ASD-PAH patients as the subjects. They were allocated randomly into control and exercise groups. Exercise group subjects performed hospital and home-based exercise programs, completing baseline 6-minute walking test (6MWT) and EQ-5D-3L QoL test (Utility Index and EQ-VAS scores), and were followed up for 12 weeks. The primary outcomes were 6MWT distance and EQ-5D-3L score at week 12. The N-terminal pro B-type natriuretic peptide (NT-proBNP) level was also assessed. A repeated-measure ANOVA was performed to detect endpoint differences over time. Results The exercise group contained 20 subjects and control group contained 19. In total, 19 exercise group subjects and 16 control group subjects completed the protocol. The 6MWT distance, Utility Index score, and EQ-VAS score incrementally improved significantly in the exercise group from baseline until week 12, with mean differences of 76.7 m (p<0.001), 0.137 (p<0.001) and 15.5 (p<0.001), respectively. Compared with the control group, the exercise group had significantly increased 6MWT distance and utility index score at week 12. The EQ-VAS score increased in the exercise group at week 12. The NTproBNP level decreased at week 12 in the exercise group. Conclusion Combined hospital and home-based exercise program added to PAH- targeted therapy, improving functional capacity and QoL in uncorrected ASD-PAH patients.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据