期刊
CHEMICAL REVIEWS
卷 120, 期 24, 页码 13135-13272出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.0c00663
关键词
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资金
- Czech Science Foundation [GA18-12477S, GJ19-20467Y]
- Czech Ministry of Education, Youth and Sports [CZ.02.1.01/0.0/0.0/17_043/0009632, EU H2020:857560]
- RECETOX research infrastructure [LM2018121]
- European Research Council (GAtransport)
- Binational Science Foundation [2016060]
- MEYS CR [LTAIN19166]
- Planning and Budgeting Committee (PBC) of the Israeli Council for Higher Education
Photoactivatable (alternatively, photoremovable, photoreleasable, or photocleavable) protecting groups (PPGs), also known as caged or photocaged compounds, are used to enable non-invasive spatiotemporal photochemical control over the release of species of interest. Recent years have seen the development of PPGs activatable by biologically and chemically benign visible and near-infrared (NIR) light. These long-wavelength-absorbing moieties expand the applicability of this powerful method and its accessibility to non-specialist users. This review comprehensively covers organic and transition metal-containing photoactivatable compounds (complexes) that absorb in the visible- and NIR-range to release various leaving groups and gasotransmitters (carbon monoxide, nitric oxide, and hydrogen sulfide). The text also covers visible- and NIR-light-induced photosensitized release using molecular sensitizers, quantum dots, and upconversion and second-harmonic nanoparticles, as well as release via photodynamic (photooxygenation by singlet oxygen) and photothermal effects. Release from photo-activatable polymers, micelles, vesicles, and photoswitches, along with the related emerging field of photopharmacology, is discussed at the end of the review.
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