期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 5, 期 12, 页码 1187-1206出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2020.09.011
关键词
cell biology/structural biology; valvular heart disease
In situ tissue engineering that uses resorbable synthetic heart valve scaffolds is an affordable and practical approach for heart valve replacement; therefore, it is attractive for clinical use. This study showed no consistent collagen organization in the predefined direction of electrospun scaffolds made from a resorbable supramolecular elastomer with random or circumferentially aligned fibers, after 12 months of implantation in sheep. These unexpected findings and the observed intervalvular variability highlight the need for a mechanistic understanding of the tong-term in situ remodeling processes in large animal models to improve predictability of outcome toward robust and safe clinical application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据