期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 12, 页码 8338-8343出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00554
关键词
polysaccharide; ultrafast degradation; tough hydrogel; biocompatibility; wound repair
资金
- National Natural Science Foundation of China [51903209]
- Natural Science Foundation of Shaanxi Province [2018JM4043]
- Natural Science Basic Research Project of Shaanxi Province [2018JQ3071]
- National Innovation and Entrepreneurship Training Program for College Students [S202010699021X]
- Analysis and Testing Center of the School of Life Sciences in Northwestern Polytechnical University
Repeatedly changing dressings during wound healing can cause unbearable physical pain for patients with chronic skin injury. In this study, we designed a tough hydrogel-based dressing that can be degraded in an on-demand fashion for advanced chronic wound care. The resultant hydrogel dressing could be rapidly dissolved within 100 s after wetting with lithium phenyl(2,4,6-trimethylbenzonyl)phosphinate solution under low-power (1 W) ultraviolet (UV) irradiation (365 nm) owing to the breakage of disulfide bonds. This UV-triggered on-demand dissolution of tough hydrogels allows for a facile dressing replacement without causing tissue damage or pain, which is of great potential for clinical utilization.
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