期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 12, 页码 9117-9125出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01343
关键词
alternating copolymer; self-assembly; polymer vesicles; photothermal effect; anti-infective therapy
资金
- National Natural Science Foundation of China [21890730, 21890733, 51773115, 81974340]
- Program for Basic Research of Shanghai Science and Technology Commission [19JC1410400]
In the past two decades, polymer vesicles have aroused widespread interest and made significant developments. However, the applications of polymer vesicles in anti-infective therapy are still limited. Here, we construct a polymer vesicle (TPPBV) from a porphyrin alternating copolymer P(TPP-a-BDE) with a high photothermal conversion efficiency (54.1%), which is attributed to the unique chain-folding mechanisms of the alternating copolymer. In particular, TPPBVs exhibit great photothermal antibacterial activity against both Gram-positive methicillin-resistant Staphylococcus aureus (MRSA) and Gram-negative extended-spectrum beta-lactamases Escherichia coli (ESBL E. coli). Moreover, TPPBVs present a specific antibiofilm effect, and they also have remarkable therapeutic effects in vivo on an MRSA-infected mice model. We believe that the porphyrin alternating copolymer vesicles for photothermal bacterial ablation reported here will extend the applications of polymer vesicles.
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