期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 11, 页码 8023-8031出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c01104
关键词
m-phenylenediamine; N@CDs; drug delivery; antibacterial activity; 2,4,6-trinitrophenol; fluorescence quenching
The synthesis of nitrogen-doped carbon dots (N@CDs) was accomplished by a hydrothermal process using meta- phenylenediamine as a source of carbon and nitrogen. As prepared N@CDs exhibited bright blue color fluorescence emission (lambda(x) = 340 nm and lambda(em) = 420 nm) with a quantum yield of 12%. Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were eradicated by N@CDs with a minimum inhibition concentration (MIC) of 1 and 0.75 mg/mL, respectively. The N@CDs were also proven as nanovesicles for drug molecules where the drug release displayed a sustained time-dependent profile at the physiological condition. The release of ciprofloxacin as a model drug was governed by the Korsmeyer-Peppas model, indicating similar to 60% of its release from the N@CD conjugated drug system at the physiological pH. Selective analysis of trinitrophenol (TNP), a popular explosive, was achieved by fluorescence quenching of N@CDs, compared favorably with other nitrophenols. An estimated detection limit of TNP was 2.45 mu M with a linear response spanning from 1 to 75 mu M.
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