期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 11, 页码 7598-7610出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00814
关键词
mesoporous silica nanoparticles (MSN); galactose and amine functionalized mesoporous silica nanoparticles (Gal-AMSN); hepatitis C Virus (HCV); JFH1; delivery vehicle
资金
- Department of Biotechnology (DBT) India
- Ministry of Human Resource Development (MHRD), Government of India
DNA and RNA based antiviral strategies using nonviral vectors have shown better potential over the viral pathway due to the fewer chances of gene recobination and immunogenicity. In this work a mesoporous silica nanoparticle (MSN) based carrier system has been used for targeted delivery of shDNA molecule against the conserved 5'-untranslated region (UTR) in the RNA of a hepatitis C virus to inhibit its replication. The MSNs coated with amine and galactose could specifically target liver cells. Significant reduction (about 94%) of viral RNA level was achieved in HCV-JFH1 infectious cell culture compared to the control RNA levels directed the successful delivery and action of the shDNA. This study showed that Gal-AMSN can be used as a synthetic delivery vector to deliver the shDNA effectively for the treatment of HCV infection.
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