期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 11, 页码 7752-7761出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00958
关键词
extremely small iron oxide nanoparticles; magnetic resonance imaging; T-1/T-2 switch; electrostatic interaction; pH responsiveness
资金
- National Natural Science Foundation of China [21807107, 81801837, 21775160]
- National Key Research and Development Program [2016YFA0101500]
- Science and Technology Foundation of Jiangsu Province [BK20180256, BK20180258, BE2018665]
- Natural Science Foundation of Jiangxi Province [20192ACBL21055]
- National Postdoctoral Program for Innovative Talents [BX201700276]
- China Postdoctoral Science Foundation [2018M632407]
Smart magnetic resonance imaging (MRI) contrast agents (CAs), whose MRI contrasting enhancement is variable in response to the specific stimulus from tumor tissues, possess great potential in precise tumor diagnosis. Herein, we design a type of extremely small iron oxide nanoparticle (ESIONP)-based pHresponsive system for activatable T-2 MRI in the tumor acid microenvironment. The ESIONP system is composed of ESIONPPEG-PGA and ESIONP-PEG-PDC, which were respectively constructed through the surface modification with poly (L-glutamic acid) (PGA) and poly(N-{N'-[N ''-(2-carbox aminoethyl)]-2-aminoethyl}glutamide) (PDC) on the surface of ESIONP. The pH-responsive system exhibits the dispersed state under the neutral condition, and when it is exposed to the weakly acid environment, ESIONP-PEG-PDC switches from the neutral to positive charge, finally leading to the aggregation by the electrostatic interaction between the positively charged ESIONP-PEG-PDC and negatively charged ESIONP-PEG-PGA. On the basis of the aggregation, the T-1 contrasting effect of the pH-responsive system switches to a T-2 contrasting effect, which can be employed to realize the selective enhancement of imaging contrast at the tumor location owing to the weakly acid microenvironment. Moreover, on the basis of size increase originated from the aggregation effect, the residence time of extremely small iron oxide nanoparticles (ESIONPs) in the tumor site is effectively prolonged, which is beneficial for the MRI of tumors. Therefore, the pH-responsive system based on the ESIONPs is a potential smart MRI contrast agent for accurate tumor diagnosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据