期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 6, 页码 3456-3475出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00156
关键词
sonodynamic therapy; ultrasound; reactive oxygen species; sonosensitizers; mechanism
资金
- National Natural Science Foundation of China [81672438, 51803087]
- Science and Technology Planning Project of Guangdong Province, China [2017A020215131]
Because of its high tissue penetrative depth, high remote spatiotemporal selectivity, and noninvasive therapeutic features, sonodynamic therapy (SDT) has received much attention in recent years. In the SDT, a tumor-localizing sonosensitizing agent is activated by ultrasound and produces greatly reactive oxygen species (ROS) to kill tumor cells. Sonosensitizers, including some organic/inorganic compounds and micro/nanoscale sonosensitizers, are an important element in SDT. Herein, we will introduce the organic/inorganic sonosensitizers and advanced micro/nanosized sonosensitizers applied in SDT. At the same time, some perspectives and the future challenges of SDT will be discussed in this review.
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