期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 6, 页码 3621-3630出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00257
关键词
hybrid biomaterials; bone tissue engineering; sol-gel process; poly(ester amide)s; tertiary bioactive glass; mesoporous silica nanoparticles
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
Designing bioactive materials for repairing or regenerating bone defects is an active area of research and discovery. Despite advances made in sol-gel-derived hybrid biomaterials design, three challenges remain: (i) the choice of biodegradable polymers that can form a homogeneous solution in the presence of water is very limited, (ii) low-temperature (below 50 degrees C) incorporation of calcium into the inorganic matrix while having molecular-level mixing has proven to be a difficult task, and (iii) incorporation of drug-loaded mesoporous nanoparticles into polymer-bioactive glass hybrid scaffolds has not been achieved. In this study, we developed bioactive biomaterials for bone repair/regeneration from an alpha-amino acid-derived biodegradable poly(ester amide) (PEA) and a tertiary bioglass (SiO2-CaO-P2O5), where calcium was incorporated into the glass network at ambient temperature. Furthermore, drug-loaded functional mesoporous silica nanoparticles prepared by surfactant templating were successfully incorporated into PEA-bioglass porous scaffolds. The resulting homogenous single-phase materials showed deposition of hydroxyapatite on their surfaces, supported mesenchymal stem cell attachment and proliferation, and showed a sustained and slow release of a model compound. Taken together, these biomaterials have the potential to be used as a bifunctional platform for bone regeneration via ion release and biomolecule delivery.
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