4.2 Article

Poly(ester amide)-Bioactive Glass Hybrid Biomaterials for Bone Regeneration and Biomolecule Delivery

期刊

ACS APPLIED BIO MATERIALS
卷 3, 期 6, 页码 3621-3630

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00257

关键词

hybrid biomaterials; bone tissue engineering; sol-gel process; poly(ester amide)s; tertiary bioactive glass; mesoporous silica nanoparticles

资金

  1. Natural Sciences and Engineering Research Council of Canada (NSERC)

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Designing bioactive materials for repairing or regenerating bone defects is an active area of research and discovery. Despite advances made in sol-gel-derived hybrid biomaterials design, three challenges remain: (i) the choice of biodegradable polymers that can form a homogeneous solution in the presence of water is very limited, (ii) low-temperature (below 50 degrees C) incorporation of calcium into the inorganic matrix while having molecular-level mixing has proven to be a difficult task, and (iii) incorporation of drug-loaded mesoporous nanoparticles into polymer-bioactive glass hybrid scaffolds has not been achieved. In this study, we developed bioactive biomaterials for bone repair/regeneration from an alpha-amino acid-derived biodegradable poly(ester amide) (PEA) and a tertiary bioglass (SiO2-CaO-P2O5), where calcium was incorporated into the glass network at ambient temperature. Furthermore, drug-loaded functional mesoporous silica nanoparticles prepared by surfactant templating were successfully incorporated into PEA-bioglass porous scaffolds. The resulting homogenous single-phase materials showed deposition of hydroxyapatite on their surfaces, supported mesenchymal stem cell attachment and proliferation, and showed a sustained and slow release of a model compound. Taken together, these biomaterials have the potential to be used as a bifunctional platform for bone regeneration via ion release and biomolecule delivery.

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