期刊
AGING-US
卷 7, 期 12, 页码 1159-1170出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100861
关键词
semi-supercentenarians; semi-supercentenarians offspring; DNA methylation; epigenetic clock; biomarker of ageing
资金
- Italian Ministry of University and Research (Project PRIN)
- European Commission [259679, 602757, 305522, 634821]
- National Institutes of Health [NIA/NIH 5R01AG042511-02, 1U34AG051425-01]
Given the dramatic increase in ageing populations, it is of great importance to understand the genetic and molecular determinants of healthy ageing and longevity. Semi-supercentenarians (subjects who reached an age of 105-109 years) arguably represent the gold standard of successful human ageing because they managed to avoid or postpone the onset of major age-related diseases. Relatively few studies have looked at epigenetic determinants of extreme longevity in humans. Here we test whether families with extreme longevity are epigenetically distinct from controls according to an epigenetic biomarker of ageing which is known as epigenetic clock. We analyze the DNA methylation levels of peripheral blood mononuclear cells (PBMCs) from Italian families constituted of 82 semi-supercentenarians (mean age: 105.6 +/- 1.6 years), 63 semi-supercentenarians' offspring (mean age: 71.8 +/- 7.8 years), and 47 age-matched controls (mean age: 69.8 +/- 7.2 years). We demonstrate that the offspring of semi-supercentenarians have a lower epigenetic age than age-matched controls (age difference=5.1 years, p=0.00043) and that centenarians are younger (8.6 years) than expected based on their chronological age. By contrast, no significant difference could be observed for estimated blood cell counts (such as naive or exhausted cytotoxic T cells or helper T cells). Future studies will be needed to replicate these findings in different populations and to extend them to other tissues. Overall, our results suggest that epigenetic processes might play a role in extreme longevity and healthy human ageing.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据