期刊
CURRENT OPINION IN PHARMACOLOGY
卷 54, 期 -, 页码 166-172出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2020.09.017
关键词
-
资金
- National Natural Science Foundation of China [21877087, 21602164, 22074114]
HIV-1 reverse transcriptase inhibitors (RTIs) are indispensable components of highly active antiretroviral therapy (HAART), which hasachievedgreatsuccess in controlling AIDS epidemicin reducing drastically the morbidity and mortality of HIV-infected patients. RTIs are divided into two categories, nucleoside reverse transcriptase inhibitors (NRTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs). In this review, the recent discoveries in NRTIs and NNRTIs, including approved anti-HIV drugs and noteworthy drug candidates in different development stages, are summarized, and their future direction is prospected.
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