期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 45, 页码 50236-50247出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c13822
关键词
poly-tetrahydropyrimidine; bacterial infection; antibacterial hydrogels; injectability; biocompatibility
资金
- National Natural Science Foundation of China [21675091, 21874078]
- Taishan Young Scholar Program of Shandong Province [tsqn20161027]
- Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407]
- Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111]
- Innovation Leader Project of Qingdao [168325zhc]
- Postdoctoral Scientific Research Foundation of Qingdao
- First Class Discipline Project of Shandong Province
Infections caused by pathogenic microorganisms have always been the Achilles heel in the clinic. In this work, to overcome this conundrum, we proposed an injectable multifunctional hydrogel material with outstanding antibacterial properties and self-healing properties and no adverse effects on health. The cross-linked hydrogel with three-dimensional (3D) networks was quickly formed via the dynamic Schiff base between amino-modified polytetrahydropyrimidine (PTHP-NH2) and multiple vanillin polymer P(DMA-VA) in 30 s. This hydrogel composite presents effective defense against both Gram-positive and Gram-negative bacteria, especially for the pyogenic Staphylococcus aureus. Moreover, the hydrogel showed almost no hemolysis and cytotoxicity. In vivo investigations indicated that hydrogels effectively killed S. aureus and protected against deterioration of inflammation. Besides, bioimaging of mice demonstrated that the hydrogel could be completely metabolized within 16 h. In a nutshell, given its outstanding antibacterial property and biocompatibility, the novel hydrogel could be an ideal candidate for the subcutaneous infection application.
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