期刊
ACS OMEGA
卷 5, 期 45, 页码 29055-29067出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c03575
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资金
- Council for Scientific and Industrial Research (CSIR), New Delhi
An economic, sustainable, and straightforward environmentally friendly synthesis of highly diversified polyfunctional dihydrothiophenes is successfully achieved via diisopropyl ethyl ammonium acetate as a room-temperature ionic liquid. Multicomponent synthesis contains domino processes; the benefit of this present protocol is highlighted by its readily available starting materials, superior functional group tolerance, purity of synthesized compounds was checked by high-performance liquid chromatography results in up to 99.7% purity for the synthesized compounds, reaction mass efficiency, effective mass yield, and excellent atom economy. In addition, a series of 2-(N-carbamoyl acetamide)-substituted 2,3-dihydrothiophene analogs were synthesized, and selected samples were chosen for testing their in vitro antibacterial and antifungal activities. Furthermore, a molecular docking study against sterol 14 alpha-demethylase could provide valuable insight into the mechanism of antifungal action providing an opportunity for structure-based lead optimization.
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