期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 46, 页码 51273-51284出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c15514
关键词
bioimaging; YAG:Nd(3+)nanoparticles; block copolymer; near-infrared fluorescence; autofluorescence removal; itanotlicimomeby
资金
- Comunidad de Madrid through TALENTO [2019-T1/IND-14014]
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Canada Foundation for Innovation
- Fonds de recherche du Quebec-Nature et technologies (FRQNT)
- French National Research Agency [ANR-17-CE09-0035-01]
- Spanish Ministry of Economy and Competitiveness project [MAT2016-75362-C3-1-R]
- Spanish Ministry of Sciences, Innovation and Universities project [PID2019-106211RB-I00]
- Instituto de Salud Carlos III [CD17/00210, PI16/00812, PI19/00565]
- Comunidad Autonoma de Madrid [B2017/BMD3867RENIMCM]
- European Structural and Investment Fund
- European Union [801305]
- Fundacion para la Investigacion Biome'dica del Hospital Universitario Ramon y Cajal project [IMP18_38(2018/0265)]
- COST action [CA17140]
- China Scholarship Council [201704910867]
- Agence Nationale de la Recherche (ANR) [ANR-17-CE09-0035] Funding Source: Agence Nationale de la Recherche (ANR)
Neodymium-doped yttrium aluminum garnet (YAG:Nd3+) has been widely developed during roughly the past 60 years and has been an outstanding fluorescent material. It has been considered as the gold standard among multipurpose solid-state lasers. Yet, the successful downsizing of this system into the nanoregimen has been elusive, so far. Indeed, the synthesis of a garnet structure at the nanoscale, with enough crystalline quality for optical applications, was found to be quite challenging. Here, we present an improved solvothermal synthesis method producing YAG:Nd3+ nanocrystals of remarkably good structural quality. Adequate surface functionalization using asymmetric double-hydrophilic block copolymers, constituted of a metal-binding block and a neutral water-soluble block, provides stabilized YAG:Nd3+ nanocrystals with long-term colloidal stability in aqueous suspensions. These newly stabilized nanoprobes offer spectroscopic quality (long lifetimes, narrow emission lines, and large Stokes shifts) close to that of bulk YAG:Nd3+. The narrow emission lines of YAG:Nd3+ nanocrystals are exploited by differential infrared fluorescence imaging, thus achieving an autofluorescence-free in vivo readout. In addition, nanothermometry measurements, based on the ratiometric fluorescence of the stabilized YAG:Nd3+ nanocrystals, are demonstrated. The progress here reported paves the way for the implementation of this new stabilized YAG:Nd3+ system in the preclinical arena.
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