期刊
AGING-US
卷 7, 期 10, 页码 754-765出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100819
关键词
parabiosis; aging; rejuvenation; stem cells; neurogenesis
资金
- NIH [R56 AG04816]
- SENS Foundation grant
This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a silver bullet putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are beyond parabiosis for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.
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