期刊
JOURNAL OF NATURAL PRODUCTS
卷 83, 期 12, 页码 3584-3590出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.0c00700
关键词
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资金
- Japan Society for the Promotion of Science KAKENHI [17K08348, 26460133]
- U.S.-Japan Cooperative Medical Sciences Program Collaborative Awards from AMED [18950036]
- NIAID [64061]
- National Natural Science Foundation of China [81673323]
- Liaoning Revitalization Talents Program [XLYC1807118]
- NIH [AI33066-27]
- Grants-in-Aid for Scientific Research [17K08348, 26460133] Funding Source: KAKEN
During a chemical investigation of Wikstroemia scytophylla, three new [wikstrocins A-C (1-3)] and three known tigliane diterpenoids (4-6) were isolated. The structures of the new compounds were elucidated from extensive physiochemical and spectroscopic analysis. The correlations between the ECD Cotton effects and B ring structures of tiglianes were also evaluated. The isolated compounds were assessed for their anti-HIV activity against HIV-1 infection of MT4 cells, and two compounds (4 and 6) showed potent anti-HIV activity with IC50 values of 3.8 and 12.8 nM, respectively.
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