期刊
TRENDS IN CANCER
卷 6, 期 12, 页码 1031-1043出版社
CELL PRESS
DOI: 10.1016/j.trecan.2020.07.007
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资金
- Dutch Cancer Society
- gravitation program CancerGenomiCs.nl from the Netherlands Organisation for Scientific Research (NWO)
- Gieskes-Strijbis Foundation [1816199]
- longterm fellowship of the European Organization for Molecular Biology (EMBO) [ALTF 765-201]
The human female reproductive tract (FRT) is a complex system that combines series of organs, including ovaries, fallopian tubes, uterus, cervix, vagina, and vulva; each of which possesses unique cellular characteristics and functions. This versatility, in turn, allows for the development of a wide range of epithelial gynecological cancers with distinct features. Thus, reliable model systems are required to better understand the diverse mechanisms involved in the regional pathogenesis of the reproductive tract and improve treatment strategies. Here, we review the current human-derived model systems available to study the multitude of gynecological cancers, including ovarian, endometrial, cervical, vaginal, and vulvar cancer, and the recent advances in the push towards personalized therapy.
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