期刊
TRENDS IN CANCER
卷 6, 期 12, 页码 1059-1067出版社
CELL PRESS
DOI: 10.1016/j.trecan.2020.07.005
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资金
- National Cancer Institute SPORE in ovarian cancer [P50 CA228991]
- Department of Defense Impact Award [W81XWH-19-1-0232]
- Dr Miriam and Sheldon G. Adelson Medical Research Foundation
- Honorable Tina Brozman 'Tina'sWish' Foundation
- Claneil Foundation
- V Foundation
- Basser Center for BRCA
- Shooting for a Cure Foundation
Over the past decade, several landmark reports have demonstrated that the nervous system plays an active role in cancer initiation and progression. These studies demonstrate that ablation of specific nerve types (parasympathetic, sympathetic, or sensory) abrogates tumor growth in a tissue-specific manner. Further, many tumor types are more densely innervated than their normal tissues of origin. These striking results raise fundamental questions regarding tumor innervation, how it is initiated, and how it molecularly contributes to disease. In this review, we aim to address what is currently known about the origin of tumor-infiltrating nerves, how they may be recruited to tumors, and how their presence may give rise to aggressive disease.
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