期刊
FEMS MICROBIOLOGY REVIEWS
卷 44, 期 6, 页码 725-739出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsre/fuaa028
关键词
Streptomyces; nucleoid-associated proteins; topoisomerase; chromosome domain; chromosome organization; chromosome topology; sporulation; regulation of gene expression; condensin
类别
资金
- Canadian Institutes of Health Research
- Boris Family Foundation
- National Science Centre, Poland [2016/22/NZ1/00122, 2018/31/D/NZ1/00287, 2018/31/B/NZ1/00614]
Chromosomes are dynamic entities, whose organization and structure depend on the concerted activity of DNA-binding proteins and DNA-processing enzymes. In bacteria, chromosome replication, segregation, compaction and transcription are all occurring simultaneously, and to ensure that these processes are appropriately coordinated, all bacteria employ a mix of well-conserved and species-specific proteins. Unusually, Streptomyces bacteria have large, linear chromosomes and life cycle stages that include multigenomic filamentous hyphae and unigenomic spores. Moreover, their prolific secondary metabolism yields a wealth of bioactive natural products. These different life cycle stages are associated with profound changes in nucleoid structure and chromosome compaction, and require distinct repertoires of architectural-and regulatory-proteins. To date, chromosome organization is best understood during Streptomyces sporulation, when chromosome segregation and condensation are most evident, and these processes are coordinated with synchronous rounds of cell division. Advances are, however, now being made in understanding how chromosome organization is achieved in multigenomic hyphal compartments, in defining the functional and regulatory interplay between different architectural elements, and in appreciating the transcriptional control exerted by these 'structural' proteins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据