期刊
AGING-US
卷 7, 期 9, 页码 664-672出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100807
关键词
cellular senescence; idiopathic pulmonary fibrosis; fibroblasts; myofibroblasts; aging
资金
- European Union [HEALTH-F4-2008-202047]
- Fund in Memory of Dr. Amir Abramovich
Idiopathic pulmonary fibrosis (IPF) is an age-related fatal disease with unknown etiology and no effective treatment. In this study, we show that primary cultures of fibroblasts derived from lung biopsies of IPF patients exhibited (i) accelerated replicative cellular senescence (CS); (ii) high resistance to oxidative-stress-induced cytotoxicity or CS; (iii) a CS-like morphology (even at the proliferative phase); and (iv) rapid accumulation of senescent cells expressing the myofibroblast marker alpha-SMA. Our findings suggest that CS could serve as a bridge connecting lung aging and its quite frequent outcome -- pulmonary fibrosis, and be an important player in the disease progression. Consequently, targeting senescent cells offers the potential of being a promising therapeutic approach.
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