期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 4, 页码 1875-1883出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.9b01010
关键词
microtubules; mechanical deformation; cargo transport; dynein; in vitro
资金
- Japan Society for the Promotion of Science (JSPS) [JP18H05423, JP16K16383]
- Hirose International Scholarship Foundation [PK22181027]
Mechanical stress on cells has profound influences on biological processes, such as cell shape regulation, the formation of tissue patterns, and development. Recently, mechanosensing properties of the microtubule, an important cytoskeletal component, have drawn attention. In this work, we studied cargo transport by dynein, a microtubule-associated motor protein, along microtubules deformed under mechanical stress. We reveal that the microtubule deformation took place as a response to the applied stress and that the deformation of microtubules facilitated the transport of dynein-driven quantum dots. This finding will provide opportunities to explore the role of microtubules as molecular mechanotransducers in cellular processes.
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