☆ 4.7 Article

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

HYPERTENSION (2017)

获取全文
添加到收藏夹

期刊

HYPERTENSION
卷 70, 期 3, 页码 E4-+

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/HYPERTENSIONAHA.117.09438

关键词

blood pressure; cardiovascular risk; complex traits; eSNP; GWAS; hypertension

类别

Peripheral Vascular Disease

资金

  1. Geneva University Hospitals
  2. Geneva University
  3. de Reuter Foundation
  4. Swiss National Foundation [FN 33CM30-124087]
  5. Fondation pour Recherches Medicales, Geneva
  6. UK Home Office [780-TETRA]
  7. National Institute for Health Research Imperial College Healthcare NHS Trust and Imperial College Biomedical Research Centre
  8. National Heart, Lung, and Blood Institute [HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN2682011000 09C, HHSN268201100010C, HHSN268201100011C, HHSN2682 01100012C, R01HL087641, R01HL59367, R01HL086694]
  9. National Human Genome Research Institute [U01HG004402]
  10. National Institutes of Health [HHSN268200625226C, HHSN268200782096C]
  11. NHGRI PAGE program [U01 HG007416]
  12. Pfizer, New York, NY
  13. Austrian Science Fond (FWF) [P20545-P05, P13180]
  14. Medical Research Council of Great Britain [G9521010D]
  15. British Heart Foundation [PG/02/128, BHF/RG/2000004, SP/04/002, SP/SP/13/2/30111]
  16. Medical Research Council [G0000934, MC_U106179471, MC_UU_12015/1, G0601966, G0700931, MR/L01632X/1]
  17. Wellcome Trust [068545/Z/02, 076113/B/04/Z, 072960/Z/03/Z, 084726/Z/08/Z, 084727/Z/08/Z, 085475/Z/08/Z, 085475/B/08/Z, 084723/Z/08/Z, WT098017, WT090532]
  18. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  19. National Institute of Allergy and Infectious Diseases (NIAID)
  20. National Human Genome Research Institute (NHGRI)
  21. National Institute of Child Health and Human Development (NICHD)
  22. Juvenile Diabetes Research Foundation International (JDRF)
  23. Juvenile Diabetes Research Foundation International
  24. Wellcome Trust
  25. National Institute for Health Research Cambridge Biomedical Research Centre
  26. Wellcome Trust Strategic Award [079895]
  27. European Commission Framework Programme 6 [018996]
  28. French Ministry of Research
  29. National Heart, Lung, and Blood Institute (NHLBI) [HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC 85083, N01HC85086, HHSN268200960009C]
  30. NHLBI [U01HL080295, R01HL087652, R01HL105756, R01HL103612, R01HL120393, R01HL130114]
  31. National Institute on Aging (NIA) [R01AG023629]
  32. National Center for Advancing Translational Sciences, CTSI grant [UL1TR000124]
  33. National Institute of Diabetes and Digestive and Kidney Disease Diabetes Research Center (DRC) grant [DK063491]
  34. Italian Ministry of Education Universities and Research [PON03PE_00060_7]
  35. FP6 [Vasoplus-037254]
  36. Assessorato Ricerca Regione Campania
  37. Fondazione con il SUD [2011-PDR-13]
  38. Istituto Banco di Napoli-Fondazione
  39. GlaxoSmithKline (GSK)
  40. Faculty of Biology and Medicine of Lausanne
  41. Swiss National Science Foundation [3200B0-105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468]
  42. Academy of Finland [139635, 129494, 118065, 129322, 250207, 269517]
  43. Orion-Farmos Research Foundation
  44. Finnish Foundation for Cardiovascular Research
  45. Sigrid Juselius Foundation
  46. Medical Research Council (UK)
  47. Ministry of Science, Education, and Sport of the Republic of Croatia [216-1080315-0302]
  48. European Union framework program 6 European Special Populations Research Network project [LSHG-CT-2006-018947]
  49. European Union framework program 7 project BBMRI-LPC [FP7 313010]
  50. Croatian Science Foundation [8875]
  51. European Commission FP6 STRP grant [018947 (LSHG-CT-2006-01947)]
  52. European Community's Seventh Framework Programme (FP7) by the European Commission under the programme Quality of Life and Management of the Living Resources of 5th Framework Programme [HEALTH-F4-2007-201413, QLG2-CT-2002-01254]
  53. Netherlands Organization for Scientific Research [NWO-RFBR 047.017.043]
  54. Russian Foundation for Basic Research [NWO-RFBR 047.017.043]
  55. ZonMw grant [91111025]
  56. Netherlands Brain Foundation [F2013(1)-28]
  57. National Instituttes of Health (NIH) [R01-DK062370, ZIA-HG000024, R01D0042157-01A, MH081802, 1RC2 MH089951, 1RC2 MH089995]
  58. CIDR NIH contract [N01-HG-65403]
  59. Liechtenstein Government
  60. Swiss National Science Foundation
  61. Swiss Heart Foundation
  62. Swiss Society of Hypertension
  63. University of Basel
  64. University Hospital Basel
  65. Hanela Foundation
  66. Schiller AG
  67. Novartis
  68. Wellcome Trust (Wellcome Trust Strategic Award STratifying Resilience and Depression Longitudinally (STRADL)) [104036/Z/14/Z]
  69. EU IMI-SUMMIT program
  70. British Heart Foundation
  71. NIHR Leicester Cardiovascular Biomedical Research Unit
  72. National Institute for Health and Welfare
  73. Finnish Centre for Pensions
  74. Social Insurance Institution of Finland
  75. Local Government Pensions Institution
  76. NIA [N01AG62101, N01AG62103, N01AG62106, 1R01AG032098-01A1]
  77. NIA Intramural Research Program
  78. Compagnia di San Paolo, Torino, Italy
  79. Fondazione Cariplo, Italy
  80. Ministry of Health, Ricerca Finalizzata
  81. CCM
  82. PRIN
  83. Telethon, Italy
  84. AstraZeneca
  85. Estonian Research Council [IUT34-12]
  86. Helmholtz Zentrum Munchen
  87. German Research Center for Environmental Health, Neuherberg, Germany
  88. German Federal Ministry of Education and Research (BMBF)
  89. German National Genome Research Network [01GS0823]
  90. Munich Center of Health Sciences (MC Health) as part of LMUinnovativ
  91. UK's Biotechnology and Biological Sciences Research Council (BBSRC)
  92. Royal Society
  93. Chief Scientist Office of the Scottish Government
  94. BBSRC
  95. Medical Research Council (MRC)
  96. Age UK (The Disconnected Mind project)
  97. Netherlands Organization of Scientific Research NWO [175.010.2007.006]
  98. Economic Structure Enhancing Fund (FES) of the Dutch government
  99. Ministry of Economic Affairs
  100. Ministry of Education, Culture and Science
  101. Ministry for Health, Welfare and Sports
  102. Northern Netherlands Collaboration of Provinces (SNN)
  103. Province of Groningen
  104. University Medical Center Groningen
  105. University of Groningen
  106. Dutch Kidney Foundation
  107. Dutch Diabetes Research Foundation
  108. NIHR [RP-PG-0407-10371]
  109. European Union FP7 (EpiMigrant) [279143]
  110. Action on Hearing Loss [G51]
  111. National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre Imperial College Healthcare NHS Trust
  112. Multi-Ethnic Study of Atherosclerosis (MESA) contracts [N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169]
  113. NCRR [UL1-RR-025005]
  114. NHLBI Contract [N02-HL-6-4278]
  115. Ministry of Health and Department of Innovation, Research and University of the Autonomous Province of Bolzano
  116. South Tyrolean Sparkasse Foundation
  117. European Union framework program 6 EUROSPAN project [LSHG-CT-2006-018947]
  118. NIH, USA [R01 HL087676]
  119. CIBERCV (Instituto Carlos III, Spain)
  120. AGAUR (Generalitat de Catalunya, Spain)
  121. Leiden University, Research Profile Area Vascular and Regenerative Medicine
  122. Dutch Science Organization (ZonMW-VENI Grant) [916.14.023]
  123. Centre National de Genotypage (Paris, France)
  124. Netherlands Organization for Scientific Research (Geestkracht program) [10-000-1002]
  125. Center for Medical Systems Biology (CSMB, NOW Genomics)
  126. Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL)
  127. VU University's Institutes for Health and Care Research (EMGO+)
  128. Neuroscience Campus Amsterdam
  129. Leiden University Medical Center
  130. Genetic Association Information Network (GAIN) of the Foundation for the National Institutes of Health
  131. BiG Grid
  132. Dutch e-Science Grid - NWO
  133. Swedish Medical Research Council [K2007-66X-20270-01-3, 2011-5252, 2012-2884, 2011-2354, 2015-03327]
  134. Foundation for Strategic Research (SSF)
  135. European Commission [01947 (LSHG-CT-2006-01947)]
  136. Swedish Society for Medical Research (SSMF)
  137. Netherlands Organization for Scientific Research (NWO)
  138. Netherlands Organisation for Health Research and Development (ZonMW) grants [904-61-090, 985-10-002, 904-61-193,480-04-004, 400-05-717, Addiction-31160008, Middelgroot-911-09-032, Spinozapremie 56-464-14192]
  139. Biobanking
  140. Biomolecular Resources Research Infrastructure (BBMRI -NL) [184.021.007]
  141. Netherlands Heart Foundation grants [86.083, 88.042, 90.313]
  142. VU Institute for Health and Care Research (EMGO+)
  143. European Community's Seventh Framework Program (FP7), ENGAGE [HEALTH-F4-2007-201413]
  144. European Research Council (ERC) [230374]
  145. Rutgers University Cell and DNA Repository [NIMH U24 MH068457-06]
  146. Avera Institute, Sioux Falls, South Dakota (USA)
  147. National Institutes of Health (NIH, Grand Opportunity grant) [1RC2 MH089951]
  148. MRC Human Genetics Unit
  149. Arthritis Research UK
  150. European Union [LSHG-CT-2006-018947]
  151. Knut and Alice Wallenberg Foundation
  152. European Research Council (ERC Starting Grant)
  153. Swedish Diabetes Foundation [2013-024]
  154. Swedish Research Council [2012-1397, M-2005-1112, 2009-2298]
  155. Swedish Heart-Lung Foundation [20120197]
  156. Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) [b2011036]
  157. European Community Sixth Framework Program [LSHM-CT-2007-037273]
  158. Swedish Research Council
  159. Swedish Heart-Lung Foundation
  160. Torsten and Ragnar Soderberg Foundation
  161. Strategic Cardiovascular Program of Karolinska Institutet
  162. Stockholm County Council
  163. Foundation for Strategic Research
  164. Stockholm County Council [560283]
  165. Wellcome Trust core award [090532/Z/09/Z]
  166. BHF Centre of Research Excellence [RE/13/1/30181]
  167. European Union Seventh Framework Programme FP7 [HEALTH-F2-2013-601456]
  168. Bristol-Myers Squibb
  169. Netherlands Heart Foundation [2001 D 032]
  170. seventh framework program of the European commission [223004]
  171. Netherlands Genomics Initiative (Netherlands Consortium for Healthy Aging) [050-060-810]
  172. Netherlands Organisation of Scientific Research NWO Investments [175.010.2005.011, 911-03-012]
  173. Genetic Laboratory of the Department of Internal Medicine, Erasmus MC
  174. Research Institute for Diseases in the Elderly [014-93-015]
  175. Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA) [050-060-810]
  176. Erasmus Medical Center
  177. Erasmus University, Rotterdam, Netherlands
  178. Organization for the Health Research and Development (ZonMw)
  179. Research Institute for Diseases in the Elderly (RIDE)
  180. European Commission (DG XII)
  181. Municipality of Rotterdam
  182. Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403, 03IS2061A, 03ZIK012]
  183. Ministry of Cultural Affairs
  184. Social Ministry of the Federal State of Mecklenburg-West Pomerania
  185. network 'Greifswald Approach to Individualized Medicine (GANI_MED)'
  186. Siemens Healthcare, Erlangen, Germany
  187. Federal State of Mecklenburg-West Pomerania
  188. Fondation pour la Recherche Medicale
  189. Caisse Nationale Maladie des Travailleurs Salaries
  190. Direction Generale de la Sante
  191. Mutuelle Generale de l'Education Nationale (MGEN)
  192. Institut de la Longevite
  193. Conseil Regionaux of Aquitaine
  194. Conseil Regionaux of Bourgogne
  195. Fondation de France
  196. Ministry of Research-INSERM Programme Cohortes et collections de donnees biologiques
  197. National Foundation for Alzheimer's Disease and Related Disorders
  198. Institut Pasteur de Lille
  199. Centre National de Genotypage
  200. LABEX (Laboratory of Excellence program investment for the future) DISTALZ-Development of Innovative Strategies for a Transdisciplinary approach to Alzheimer's disease
  201. French National Foundation on Alzheimer's disease and related disorders
  202. Economic and Social Research Council
  203. Netherlands Organization for Scientific Research NWO (Medical Research Council program) [GB-MW 940-38-011]
  204. Netherlands Organization for Scientific Research NWO (ZonMW Brainpower grant) [100-001-004]
  205. Netherlands Organization for Scientific Research NWO (ZonMw Risk Behavior and Dependence grants) [60-60600-97-118]
  206. Netherlands Organization for Scientific Research NWO (ZonMw Culture and Health grant) [261-98-710]
  207. Netherlands Organization for Scientific Research NWO (Social Sciences Council medium-sized investment grants) [GB-MaGW 480-01-006, GB-MaGW 480-07-001]
  208. Netherlands Organization for Scientific Research NWO (Social Sciences Council project grants) [GB-MaGW 452-04-314, GB-MaGW 452-06-004]
  209. Netherlands Organization for Scientific Research NWO (NWO large-sized investment grant) [175.010.2003.005]
  210. Netherlands Organization for Scientific Research NWO (NWO Longitudinal Survey and Panel Funding) [481-08-013, 481-11-001]
  211. Dutch Ministry of Justice (WODC)
  212. European Science Foundation (EuroSTRESS project) [FP-006]
  213. Biobanking and Biomolecular Resources Research Infrastructure BBMRI-NL [CP 32]
  214. Netherlands Scientific Organization [NWO 480-05-003]
  215. Ministry for Higher Education
  216. GenomEUtwin [QLG2-CT-2002-01254, EU/QLRT-2001-01254]
  217. NIH grant [DK U01-066134]
  218. SNIC through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX) [b2011036]
  219. European Community's Seventh Framework Programme (FP7)
  220. National Institute for Health Research (NIHR) BioResource Clinical Research Facility and Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London [guysbrc-2012-1]
  221. National Institutes for Health Research (NIHR) as part of the portfolio of translational research of the NIHR Biomedical Research Unit at Barts
  222. National Institute for Health Research (NIHR) Biomedical Research Unit in Cardiovascular Disease at Barts
  223. China Scholarship Council [2011632047]
  224. MRC eMedLab Medical Bioinformatics Career Development Fellowship [MR/L016311/1]
  225. National Institutes for Health Research (NIHR) Imperial College Health Care NHS Trust and Imperial College London Biomedical Research Centre
  226. UK Medical Research Council
  227. Public Health England
  228. [U01 DK062418]
  229. [N01-HC-25195]
  230. Swedish Research Council [2015-03327] Funding Source: Swedish Research Council
  231. BBSRC [BB/F019394/1] Funding Source: UKRI
  232. ESRC [ES/H029745/1] Funding Source: UKRI
  233. MRC [MR/M501633/1, MR/N01104X/2, MR/L01632X/1, G0601966, MR/N015746/1, MC_PC_U127561128, MR/M501633/2, MR/L016311/1, MR/K007017/1, MR/N003284/1, G0600237, MC_UU_12015/1, G0700931, MR/N01104X/1, MR/L01341X/1, G9521010, G1001799] Funding Source: UKRI
  234. Vinnova [2015-03327] Funding Source: Vinnova
  235. Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
  236. British Heart Foundation [RG/15/12/31616, FS/12/82/29736, SP/13/2/30111] Funding Source: researchfish
  237. Cancer Research UK [14136] Funding Source: researchfish
  238. Economic and Social Research Council [ES/H029745/1] Funding Source: researchfish
  239. Medical Research Council [MC_UU_12015/1, MR/N015746/1, G0700931, MR/K026992/1, G9521010, G1001799, MR/L01341X/1, MR/M501633/1, MR/L01632X/1, MR/N003284/1, MR/N01104X/2, MR/K006584/1, MC_PC_13040, G1000143, MC_PC_U127561128, MC_U106179471, MR/N01104X/1, MR/M501633/2, MC_PC_13046, MC_PC_13048, MR/K007017/1, G0401527, G0600237, MR/L016311/1, G0601966] Funding Source: researchfish
  240. National Institute for Health Research [NF-SI-0512-10113, NF-SI-0611-10136, NF-SI-0512-10114, NF-SI-0513-10059] Funding Source: researchfish
  241. Academy of Finland (AKA) [129322] Funding Source: Academy of Finland (AKA)

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA. Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据
研讨会 海报 问题 讨论圈 基金 期刊 论文 科研社交 资讯集成 审稿人 关于我们 常见问题 移动App 隐私条款 使用条款
© Peeref 2019-2024. All rights reserved.