期刊
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
卷 32, 期 2, 页码 -出版社
WILEY
DOI: 10.1002/hup.2574
关键词
adverse effect; aetiology; brain; follow-up; MRI; psychotic disorders
资金
- Sigrid Juselius foundation
- Oy H Lundbeck Ab
- Academy of Finland [268336, 278286]
- Jalmari and Rauha Ahokas foundation
- Brain & Behavior Research Foundation
- Northern Finland Health Care Support Foundation
- Academy of Finland (AKA) [268336, 268336, 278286, 278286] Funding Source: Academy of Finland (AKA)
Objective The association between long-term antipsychotic treatment and changes in brain structure in schizophrenia is unclear. Our aim was to conduct a systematic review and a meta-analysis on long-term antipsychotic effects on brain structures in schizophrenia focusing on studies with at least 2 years of follow-up between MRI scans. Design Studies were systematically collected using 4 databases, and we also contacted authors for unpublished data. We calculated correlations between antipsychotic dose and/or type and brain volumetric changes and used random effect meta-analysis to study correlations by brain area. Results Thirty-one publications from 16 samples fulfilled our inclusion criteria. In meta-analysis, higher antipsychotic exposure associated statistically significantly with parietal lobe decrease (studies, n = 4; r = -.14, p = .013) and with basal ganglia increase (n = 4; r = .10, p = .044). Most of the reported correlations in the original studies were statistically nonsignificant. There were no clear differences between typical and atypical exposure and brain volume change. The studies were often small and highly heterogeneous in their methods and seldom focused on antipsychotic medication and brain changes as the main subject. Conclusions Antipsychotic medication may associate with brain structure changes. More long-term follow-up studies taking into account illness severity measures are needed to make definitive conclusions.
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