期刊
HUMAN MOLECULAR GENETICS
卷 27, 期 3, 页码 475-485出版社
OXFORD UNIV PRESS
DOI: 10.1093/hmg/ddx417
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资金
- National Nature Science Foundation of China [81571099, 31771123]
- Key Research Program of Frontier Sciences, CAS [QYZDB-SSW-SMC046]
- Beijing Brain Project [Z16110000266004]
- Program of International S and T Cooperation [2015DFA31580]
- Recruitment Program of the Global Youth Experts of China
LncRNAs have recently emerged to influence the pathogenesis of fragile X syndrome (FXS), which is caused by the functional loss of fragile X mental retardation protein (FMRP). However, the interaction between FMRP and lncRNAs on regulating neuronal development remains elusive. Here, we reported that FMRP directly interacted with lncRNA TUG1, and decreased its stability. Furthermore, TUG1 bond to transcriptional regulator, SnoN, and negatively modulated SnoN-Ccd1 pathway to specifically control axonal development. These observations suggested interplay between FMRP and lncRNAs might contribute to the pathogenesis of FXS.
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