期刊
HUMAN BRAIN MAPPING
卷 38, 期 3, 页码 1702-1715出版社
WILEY
DOI: 10.1002/hbm.23499
关键词
FSL-Nets; networks; Lewy body disease; fMRI; brain connectivity
资金
- National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals NHS Foundation Trust
- Newcastle University
- EPSRC [EP/K026992/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K026992/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0616-10011] Funding Source: researchfish
- Parkinson's UK [G-1301] Funding Source: researchfish
Mild cognitive impairment (MCI) is prevalent in 15%-40% of Parkinson's disease (PD) patients at diagnosis. In this investigation, we study brain intra- and inter-network alterations in resting state functional magnetic resonance imaging (rs-fMRI) in recently diagnosed PD patients and characterise them as either cognitive normal (PD-NC) or with MCI (PD-MCI). Patients were divided into two groups, PD-NC (N562) and PD- MCI (N537) and for comparison, healthy controls (HC, N530) were also included. Intra- and inter-network connectivity were investigated from participants' rsfMRIs in 26 resting state networks (RSNs). Intra-network differences were found between both patient groups and HCs for networks associated with motor control (motor cortex), spatial attention and visual perception. When comparing both PD-NC and PD-MCI, intra-network alterations were found in RSNs related to attention, executive function and motor control (cerebellum). The inter-network analysis revealed a hyper-synchronisation between the basal ganglia network and the motor cortex in PD-NC compared with HCs. When both patient groups were compared, intra-network alterations in RSNs related to attention, motor control, visual perception and executive function were found. We also detected disease-driven negative synchronisations and synchronisation shifts from positive to negative and vice versa in both patient groups compared with HCs. The hyper-synchronisation between basal ganglia and motor cortical RSNs in PD and its synchronisation shift from negative to positive compared with HCs, suggest a compensatory response to basal dysfunction and altered basal-cortical motor control in the resting state brain of PD patients. (C) 2017 Wiley Periodicals, Inc.
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