期刊
CRITICAL REVIEWS IN IMMUNOLOGY
卷 35, 期 3, 页码 185-202出版社
BEGELL HOUSE INC
DOI: 10.1615/CritRevImmunol.2015013844
关键词
metapneumovirus; pulmonary inflammation; viral infection; lung T cells; IgG1; IgG2a
类别
资金
- Fondo Nacional de Ciencia y Tecnologia (FONDECYT-CHILE) [1140010, 1150862, 1130996, 3120019]
- CONICYT/FONDECYT [3140455]
- Fondo de Fomento al Desarrollo Cientifico y Tecnologico (FONDEF-CHILE) [D11I1080]
- Programa Consorcios Tecnologicos para la Innovacion-Consorcio Tecnolo'gico en Biomedicina BMRC from Innova-CORFO Chile [13CTI-21526]
- Instituto Milenio en Inmunologia e Inmunoterapia [P09/016-F]
- Innova-CORFO Chile [11IDL2-10668]
- Grant Nouvelles Equipes-nouvelles thematiques from the La Region Pays De La Loire
Acute respiratory tract infections (ARTIs) are the major cause of child mortality worldwide. The human metapneumovirus (hMPV) is one of the leading causes of child hospitalizations due to pneumonia. The adaptive immune response generated by the host against hMPV is usually inefficient at protecting from reinfections, which is repeat throughout life, from childhood to old age. Despite considerable research efforts, to date there are no licensed vaccines to prevent respiratory disease caused by hMPV infection. In this article we review current vaccine strategies tested in animal models and the implication of such studies in understanding the different immune cell populations that contribute to hMPV clearance and the prevention and resolution of lung inflammation upon exposure to the virus.
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