期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 10, 页码 6876-6887出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00794
关键词
mesoporous silica; gold nanorods; NIR-II biowindow; brain drug delivery; blood-brain barrier; neurodegenerative disorders
资金
- Guangdong Basic and Applied Basic Research Foundation [2019B1515120043]
- National Research and Development Program for Major Research Instruments [81527801]
- National Key Research and Development Program [2016YFC1000701]
- University of Macau [MYRG2019-00121-ICMS, MYRG2018-00207-ICMS]
- National Natural Science Foundation of China [U1801681]
- Key Field Research and Development Program of Guangdong Province [2018B030337001]
Despite the relative severity of Parkinson's disease (PD), to date, there has been only limited success in preventing or treating this condition owing to the low permeability of the blood-brain barrier (BBB), which makes the cerebral delivery of pharmaceutical agents very challenging. In the present study, we explored an approach to increasing BBB permeability via the use of mesoporous silica-encapsulated gold nanorods (MSNs-AuNRs) that could reliably achieve a robust photothermal effect in response to second near-infrared (NIR-II) irradiation. To test the potential anti-Parkinsonian activity, we loaded MSNs-AuNRs with the frequently utilized anti-PD agent quercetin (QCT) to yield MSNs-AuNRs@QCT. Following NIR-II irradiation, we observed a dramatical increase in QCT transfer through the BBB, indicating that MSNs-AuNRs may enhance BBB permeability via the photothermal effect. These findings were further supported by rat pharmacokinetic studies, which clearly revealed that the combination of MSNs-AuNRs and NIR-II irradiation was associated with significantly improved brain accumulation. In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced murine model of PD, we also found that intravenous MSNs-AuNRs@QCT delivery and subsequent NIR-II irradiation was sufficient to markedly reduce the neurological abnormalities in these mice. Together, this combination offers promising potential as a nanoplatform for neuroprotective drug delivery and treatment of PD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据