期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 10, 页码 7103-7112出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00933
关键词
supramolecular hydrogels; host-guest systems; mechanical robustness; fatigue resistance; self-healing
资金
- National Natural Science Foundation of China [51603041]
- Natural Science Foundation of Fujian Province of China [2017Y0058]
Natural polymer-based hydrogels attract great attention because of their inherent biocompatibility and controllable biodegradability. However, the broad applications of these hydrogels require a combination of high mechanical strength, high toughness, fatigue resistance, as well as self-healing. The integration of this combination into one natural polymer-based hydrogel remains challenging. Here, a molecular design strategy was proposed to fabricate mechanically robust silk fibroin-based hydrogels using host-guest interactions. Silk fibroin molecules was chemically modified with cholesterol (Chol, guest) or beta-cyclodextrin (beta-CD, host), and host-guest interaction between Chol and beta-CD moieties drove the supramolecular assemblies of hydrogels. The dissociation/reassociation behavior of host-guest complexation, serving as sacrificial bonds, endowed hydrogels with effective energy dissipation and rapid self-healing ability. The prepared silk fibroin-based hydrogels exhibited high mechanical strength, high toughness, and remarkable fatigue resistance, superior to conventional silk fibroin hydrogels. Moreover, due to reversible host-guest interactions, hydrogels achieved facile functional recovery after damage without any external stimuli. This design strategy provides an avenue to develop natural polymer-based materials with robust mechanical properties, thus broadening current hydrogel applications.
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