期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 10, 页码 6556-6570出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00867
关键词
cell encapsulation; multilayers; layer-by-layer coating; polymer; cell coating; layer assembly
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1A5A1018052, 2017M3A7B8061942, 2019R1A2C1006018]
- National Research Foundation of Korea [2017M3A7B8061942, 2019R1A2C1006018] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The complete recovery of tissues or cells damaged by an accident or illness is a major issue in medicine. With increasing medical costs and incidences of incurable diseases, this aspect is emerging as an important human health problem worldwide. However, reproducing actual cells and tissues is not easy because of the involvement of several variables. External environmental changes such as different pH levels, the presence of oxidants, and ultraviolet exposure can impair cell function or trigger cell death owing to the limitations of the cells. In addition, transplanted therapeutic cells die easily owing to inflammatory and immune responses. Efforts to overcome this problem through multilayer cell coating can provide avenues for diagnosis and basic cell biology studies owing to the following features of multilayer films: (i) high capacity available for attaching different biomolecules; (ii) natural replication of signal molecule diffusion across cells; and (iii) the possibility of cell patterning. Furthermore, light-triggered release from multilayer films achieves the delivery of biomolecules with a high spatiotemporal resolution. In this study, we reviewed the methods and recent innovations in multilayer cell coatings that demonstrate a strong potential for applications in biomolecule loading, cell patterning, and biosensors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据