期刊
ACS APPLIED BIO MATERIALS
卷 3, 期 10, 页码 6746-6755出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.0c00692
关键词
alginate; hydroxyapatite; nanocomposite; nanofiber; scaffold
资金
- Natural Science and Engineering Research Council of Canada (Discovery Projects Process engineering for smart bioceramics NSERC RGPIN) [121269-09]
We report herein the structural and mechanical properties and in vitro cellular response of hydroxyapatite (HAp)/alginate nanocomposite fibrous scaffolds mimicking the mineralized collagen fibrils of bone tissue. The biomimetically engineered nanocomposites, fabricated by electrospinning and in situ synthesis strategy, were compared with pure alginate nanofibers and micrometer-level HAp/alginate composite fibers. The tensile strength and elastic modulus of the nanocomposites increased by 79.3 and 158.4%, respectively, compared to those of alginate. The uniform nucleation and HAp nanocrystal growth on the alginate nanofibers resulted in such enhancement of the mechanical properties via a stress-transfer effect. Rat calvarial osteoblasts were stably attached and stretched more extensively on the nanocomposites' surface than on the pristine alginate. The controlled deposition of the HAp nanophase contributed to a much faster cell proliferation rate on the nanocomposites than on the others. The improved structural stability and osteoblast interactions suggest the fibrous nanocomposite scaffold's potential advantages for bone tissue regeneration.
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